產品介紹

 AD-1 

K_v1.3 channel blocker(鉀離子通道K_v1.3阻斷劑)

AD-1 is an optimised synthetic analog of the scorpion peptide BmKTx. AD-1 is known to block voltage-gated mK_v1.3 channel with a high affinity (IC₅₀ = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).AD-1 inhibits CD4⁺ CCR7^- T-cell proliferation. AD-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of K_v1.3 channel and auto-immunity pathways. 
 

AD-1 技術資料

氨基酸序列：

Val-Gly-Ile-Asn-Val-Lys-Cys⁷-Lys-His-Ser-Arg-Gln-Cys¹³-Leu-Lys-Pro-Cys¹⁷-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁷-Thr-Asn-Gly-Lys-Cys³²-His-Cys³⁴-Thr-Pro-Lys-OH

二硫鍵：Cys⁷-Cys²⁷, Cys¹³-Cys³², Cys¹⁷-Cys³⁴ 

長度 (aa)：  37

分子式：C₁₆₉H₂₈₁N₅₇O₄₆S₇   

分子量： 4071.90 Da 

外觀： White lyophilized solid

可溶性： water and saline buffer

CAS 號：not available

來源： Synthetic

純度： > 98%

產品信息